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KMID : 0371619870030020285
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Journal of Wonkwang Medical Science
1987 Volume.3 No. 2 p.285 ~ p.292
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A Morphological Study on the Effect of Acetaldehyde on the Early Development Mouse Embryos in vitro
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金大昊/Kim, Dae Ho
文蓮子/禹元洪/朴承澤/鄭然泰/Mun, Yeun Ja/Woo, Won Hong/Park, Seung Taeck/Chung, Yeun Tai
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Abstract
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In an attempt to elucidate the effect of Acetaldehyde on the development of mouse early embryo, the two-cell stage was cultured for 72 hours in the medium containing various concentrations of Acetaldehyde.
Cytotoxicity of Acetaldehyde was studied for the embryonal cells differentiated from two-cell stage to blastocyst in the Acetaldehyde contained medium.
The following results were obtained.
1. When two-cell stage was cultured for 72 hours at various concentrations of Acetaldehyde, the development of early embryos was suppressed remarkably at 2.5 X 10-4 M of Acetaldehyde.
2. Acetaldehyde decreased the number of embryos developed toblastocysts, dose-dependently and the longer the embryos exposed to Acetaldehyde, the more injury appeared.
3. Cytotoxicity of Acetaldehyde was pronounced such a morphological changes as cytolysis, fusion, developmental retardation and fragmentation of biaston,eres, dose-dependently in the embryonal cells damaged to Acetaldehyde.
From the above results, it is suggested that Acetaldehyde might have a toxic effect on the development of´, mouse early embryo by inhibiting the cleavage of embryonal cell.
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